Drones work now because they are $1000 (random number in the right range), while a patriot missile is $4 billion dollars each. Sure you could shoot a drone down with one, but if you do the enemy will just send more and bankrupt you.
Ukraine has already seen some success using WWII air defense rifles, or hunting shotguns to take out drones, there the cost is around $1 each. It will need more effort, but there is no reason we cannot automate building such things, and from there mass production means drones are no longer cost effective because they get shot down. (note that shotguns have a range of about 50 meters, and the rifles maybe 10km - we need a lot of this on the lines to make a difference, but that means large amounts of mass production and so the cost should be maybe $5-10k each)