I like going for a punkish aesthetic and I have two ear piercings, nose piercing, and two tattoos on my arms, one that's patterns with some skulls the other one is an anchor with "sink or swim" on it
I got my first at 31 (33 now). I have 2 now, and have plans for more. I was constantly wishy washy about what I'd want, and decided to just do something simple for my first, I got the outline of the James Webb Space Telescope main mirror on the back of my calf. Figured someday I could either fill it in with some cool space-y patterns, or incorporate it into some other piece. For a while I thought about filling it with parts of the first JWST deep-field shot, and also getting a bee with a space helmet (since the mirrors are hexagonal it kinda looks like a honeycomb, and bees are cool), but I couldn't figure out any way to make a bee look reasonable with a space helmet, so dropped the bee plan lol.
I have lots of weird little "widgets" I love and would probably hold close to my heart forever (Mr Toad, Quar, etc.) so I suppose a mishmash of things is as good as something "meaningful". And I guess those things are more likely to stay dear to me over something "big"!