Spanish researchers discover possible key to enhance immunotherapy cancer treatment: anti-inflammatories such as aspirin

The study also sheds light on cancer’s strategy for hiding from defenses. Tumor cells increase the production of prostaglandin E2, a lipid substance that blocks the action of monocytes. At the same time, they decrease the production of interferons, proteins that stimulate the immune system. The Vienna group argues that anti-inflammatory drugs that inhibit cyclooxygenase, such as aspirin, are “a promising strategy” to increase the effectiveness of immunotherapy, since they block the production of inflammatory molecules, such as prostaglandin E2.

Interesting as aspirin, acetaminophen, and ibuprofen all inflame the gut to some degree, so although they reduce inflammation in the rest of the body your GI doesn't react well.

Interesting trade off. Amazing development in understanding!

A bit of something new here, but we've known this for awhile. It's not a viable long-term solution but if they're talking the scope of just the treatment phase, maybe useful for some.

I'll try and find the study, but this was almost the exact outcome of one done awhile back trying to find the correlation between patients with autoimmune diseases taking suppressants that had essentially no occurrences of malignant cancer over decades, but markers present. They found a strong correlation to regular DMARD doses and regular use of NSAIDs to be the cause. It makes your body essentially uninhabitable for cancer. Obviously, not everyone could/should be on such regimens throughout their life to prevent cancer lol.