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Imidazole propionate is a driver and therapeutic target in atherosclerosis

www.nature.com /articles/s41586-025-09263-w

Nature, Published online: 16 July 2025; doi:10.1038/s41586-025-09263-w

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.


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