Star Trek actors are the most robust actors. They're everywhere. I watched all of Boston Legal without realizing it wasn't Star Trek. Our boy Frakes plays adult Finn in the adventure time episode Puoy, George plays Ricardio. You can't escape it. Star Trek encompasses all.
Edit: sort of unnecessary edit but when I use actors here it is gender neutral.
It's especially great when they do something that's completely off the walls crazy. Michael Dorn played a screaming dwarf in the Billy and Mandy episode "Here There Be Dwarves," who went mad after centuries of mushroom farming and exacted his revenge by invading the Keebler elves' hollow tree. Then R. Lee Ermey pops up to censor the carnage and the dwarves and elves compromise by making mushroom cookies, and Billy does karaoke. That show was so delightfully warped and random sometimes.
I definitely remember recognizing Frakes, Dorn, and de Lancie while playing through the War of the Chosen expansion for XCOM2. Also René Auberjonois on a few of the Uncharted games as well.
Yes, it certainly was! For some reason I didn't recognize their voices. It wasn't until I looked up the voice cast list to check the three that I mentioned that I found they were on it too!
George Takei killed it in his role in Yakuza: Like a Dragon. (Literally and figuratively, he played a hitman-come-mob boss and a father figure to the game’s protagonist.) I wish he had more screen time in the role.
Picardo does a fine job as the Institute scientist who is in charge of synth production; seemed very much like the EMH's role and he seemed to play it that way.
Russ, though... He's a Brotherhood of Steel guy on the Prydwyn and just seems like a more stern version of Tuvok. Not because the role called for it, but because he was just reading lines without any passion behind them. Or wasn't given proper direction (which given some things other VAs who worked on that have said is probably closer to the truth).
Patrick Stewart has also lent his voice to a Bethesda game as Uriel Septim in Oblivion.
Admin Shimmerman is in Starfield and I think it's great because his character there is a billionaire corpo dude which reminds me Quark.
Oh and I can't forget that William Shatner not only gave his voice to, he also literally wrote TekWars.