Running TrueNAS scale within Proxmox. Any disadvantages?

I am having trouble deciding between Proxmox and TrueNAS scale for a homelab on my Dell OptiPlex. I am worried that I'll be limited by TrueNAS at some point, so why not just make it a VM? Will there be any significant performance loss if I just make a TrueNAS VM within Proxmox and give it all the resources? I have a total of 4x 8TB HDDs. One isn't functioning but I'm pretty sure I can fix it, although I don't trust it now.

Or perhaps Proxmox is unnecessary for my use case? Please let me know what you think! I intend to run the following:

PiHole with Unbound DNS Jellyfin Home Assistant with smart devices on separate VLAN Playing around with webhosting, maybe even a small personal Lemmy server. Miniflux RSS Personal documentation solution such as Logseq

I also have a few spare Raspberry Pis and I'm wondering if they could be made into Proxmox nodes...