You can play Doom using gut bacteria, but the framerate is atrocious

It’s worth noting that Ramlan herself points out that “running” Doom using the cells would be an enormous undertaking due to their extremely limited ability. What she did manage to successfully do, however, is use the wall of cells as a display for Doom by rendering gameplay using the illuminated E. coli.

It's interesting but it's not running doom but serve as a display.

Oddly reminds me of a twitter bot account I used to like called Doom Clock (I think) that posted 1 frame screenshot from the demo of the current world record speed run every hour. Pretty fun way to randomly remember various parts of the game while doom-scrolling.