and the fish asked "what is this water you speak of?"

Wouldn't the Bernie Sanders "I'm once again asking for your support" fall into that category? I've seen it used for lolz in all sorts of topics that had nothing to do with politics. Same for any other memes featuring political figures

That Is Correct.

One thing about which fish know exactly nothing is water, since they have no anti-environment which would enable them to perceive the element they live in.

• Marshall McLuhan, War and Peace in the Global Village