| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ⁷ Oregon | ^T-25 USC | Sat 11/11, 10:30 PM ET | Autzen Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | BYU | Iowa State | Sat 11/11, 10:15 PM ET | LaVell Edwards Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | UCLA | Arizona State | Sat 11/11, 9:00 PM ET | Rose Bowl | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | North Carolina | Duke | Sat 11/11, 8:00 PM ET | Kenan Memorial Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ²¹ LSU | ^T-25 Florida | Sat 11/11, 7:30 PM ET | Tiger Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ¹ Ohio State | Michigan State | Sat 11/11, 7:30 PM ET | Ohio Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | UT San Antonio | Rice | Sat 11/11, 7:30 PM ET | Alamodome | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Texas A&M | Mississippi State | Sat 11/11, 7:30 PM ET | Kyle Field | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ^T-4 Georgia | ¹⁰ Ole Miss | Sat 11/11, 7:00 PM ET | Sanford Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Houston | Cincinnati | Sat 11/11, 7:00 PM ET | John O'Quinn Field at TDECU Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ¹² Oklahoma | West Virginia | Sat 11/11, 7:00 PM ET | Gaylord Family Oklahoma Memorial Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ^T-15 Oregon State | Stanford | Sat 11/11, 5:30 PM ET | Reser Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Arkansas | Auburn | Sat 11/11, 4:00 PM ET | Donald W. Reynolds Razorback Stadium Frank Broyles Field | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | California | Washington State | Sat 11/11, 4:00 PM ET | California Memorial Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Syracuse | Pittsburgh | Sat 11/11, 3:30 PM ET | Yankee Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | UCF | ¹⁹ Oklahoma State | Sat 11/11, 3:30 PM ET | Bright House Networks Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ² Florida State | Miami | Sat 11/11, 3:30 PM ET | Bobby Bowden Field at Doak Campbell Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | ²⁴ Iowa | Rutgers | Sat 11/11, 3:30 PM ET | Kinnick Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Purdue | Minnesota | Sat 11/11, 3:30 PM ET | Ross-Ade Stadium | |

| Home | Away | Time | Venue | Notes | | - | - | - | - | - | | Wisconsin | Northwestern | Sat 11/11, 3:30 PM ET | Camp Randall Stadium | |