I did another "starting weapon upgrade dump challenge": The Mage. Easy right? Then I fucked it up by cursing my staff.
Once again I put every possible upgrade into Studded Gloves, and this time I never once took them off and also ascended with the amulet!
"Ascended with the Amulet" with 23 Potions of Healing + six challenges enabled (Shattered Pixel Dungeon)