I've always been annoyed about how DuBois, Pennsylvania is pronounced. Everyone I knew would say "Dew-Boys". Uh, okay. I mean, people with that last name must facepalm all the time over that.
I mean, I know most people would just call the Schuylkill Express the Surekill Express as a joke, but even if they didn't, I guess the usual pronunciation approximates how it was said in Dutch (I guess?) - skool-kil. Also, it's not a common last name that I know of. DuBois, on the other hand...
PA has its share of oddness....Intercourse, PA, Blue Ball, PA, and Middlesex township....all the things named Beaver around State College...