Every damn time.

Why always mice ? Why not testing it straight to human ? We got never ending supply of human here in this planet

People get a bit grumpy when you "permanently maim a bunch of people to see what happens"
Idk sounds like liberal bullshit to me /s
Because people did that and that's pretty bad
- "Wdym Unit 731 and Dr. Mengele?"
- It's not bad to use child molesters.

Remember Trump unironically, seriously saying we should consider spraying bleach into lungs to treat COVID?
Guys...
I have an idea to get rid of tumors
Just so you know when they say invitro that means in a petri dish, maybe a better example than a gun is bleach, yeah it works against any virus, but it will also kill you.

Where can I acquire these mouses?

Mice are excellent models for many diseases but not all. When possible we study cell culture, then mice, then humans and there are rigorous ethics committees that require justification for the study, we don't just do these studies for no reason. Their metabolism and physiology is pretty similar to ours, which makes them useful to study inflammation, cancer, diabetes and other malignant/metabolic/genetic disorders. They have a 21 day gestation period and research mice are essentially all clones which eliminates genetic variability as a factor (making them excellent for reproducibility in a timely manner)

some drawbacks include the spine, they're haunched which makes it difficult to study something like scoliosis, we do this in zebrafish actually. Also I believe they have some mild immunological differences like ratio of circulating white cells and bone marrow differentials and minor differences in some proteins. Basically anyone doing these studies has years of training and really knows what they are doing, they would not be allowed to conduct them unless it was absolutely necessary to answer a specific question. Mouse work is a lot more complicated/interesting than this but I think I've made my point for now.

Source: wrote a portion of my thesis on justification of using an animal model for obesity research, then an 8 year career in a pathology core/phenotyping lab.

Mice have the best healthcare.

Er, yes but also this...
https://www.braintreesci.com/restraint-containment-handling/restraint/rat-restrainers/decapicones/
Make injections and decapitation quicker and easier with Braintree Scientific's DecapiCones. Tapered plastic film tubes provide quick and easy restraint of rats, mice, and other small animals. I.P. injections can be made directly through the film! DecapiCones restrain post-decapitation kicking and prevent personal contact with feces or urine. A unique dispenser holds DecapiCones open and ready for use. Simply hold the DecapiCone in one hand and introduce the animal with the other. Animals enter readily, heading for the breathing hole at the small end. Roll and squeeze the large end closed. They may be used repeatedly for injections and simply discarded when soiled. For decapitation, hold at the rear and insert the small end into the decapitator.
They come in quantities of 200, in handy pre-loaded dispensers.
- Can’t believe that name. Wow.
- Good god, this text is real
  Looked up decapitators... https://stoeltingco.com/Neuroscience/Decapitators~9997
  "Rodent guillotine" https://www.wpiinc.com/var-2645-rodent-guillotine.html
- Man, my oldest kiddo is going into neuroscience, there are paid internship opportunities, which is awesome but I worry she'll end up using something like these to snuff mice all day. I don't think I could do that job.
Well they better, in california everything gives them cancer.

Got to start somewhere. Can't jump directly into human trials.

Well, yes you can, but it’s considered „inhumane“ and „unethical“
https://en.m.wikipedia.org/wiki/Unethical_human_experimentation
(German „quotation marks“ for stylistic purposes)
- Literally the rhetoric that the Nazis used as an excuse to experiment on Jews in concentration camps
- Be the change you want to see in the world! Volunteer for medical trials today!
- Hello Adolph

Mice in LSD trials:

Relevant PBF comic

Those pesky ethics committees...

The success rate in humans for something discovered in mice is about 1 in 100.

So a lot of the scientific journalism presenting a mouse model as a major discovery that will revolutionise [X disease] is straight up bad faith clickbait.

Scientists are spending time and money to torture mice simply for fun with no practical use? Sounds very believable
- Not for fun.
  For grants, citations, and professional legitimacy. Ie. to keep up with the metrics required to not lose your job in modern research.

Skaven using humans to develop the latest health care.

We'll make mice immortal before going extinct...

[...] MAY [...]

Vitro la Vida and Death and all his Friends