LW: CRISPR Will Make Me A Genius - "I don’t have a formal background in biology. And though I learn fairly quickly and have great resources like SciHub and GPT4,"
Significantly Enhancing Adult Intelligence With Gene Editing May Be Possible — LessWrong
archive: https://archive.is/KdzMM
Genetically altering IQ is more or less about flipping a sufficient number of IQ-decreasing variants to their IQ-increasing counterparts. This sounds overly simplified, but it’s surprisingly accurate; most of the variance in the genome is linear in nature, by which I mean the effect of a gene doesn’t usually depend on which other genes are present
Contradicted by previous text in the same article (diabetes), not to mention have you even opened a college-level genetics text in the last decade?
Anyway, I would encourage these people to flip their own genome a lot, except that they probably won't take the minimum necessary precautions of doing so under observation in isolation. "Science is whatever people in white coats say it is, and I bought a nice white coat off Amazon!"
most of the variance in the genome is linear in nature, by which I mean the effect of a gene doesn’t usually depend on which other genes are present
that person seems homeschooled on absolute bullshit; basic high school biology course thirty-odd years ago was saying otherwise.
that person seems homeschooled on absolute bullshit
the yudkowsky tradition! cause skimming a book and reconstructing the rest of the knowledge on your gut feelings is a perfectly good substitute for going to fucking school, Eliezer
Meanwhile actual discussions about biotech are more like
"Is it feasible to get widespread changes in an organism we want or are biological systems hopelessly and fundamentally complex making this impossible?"
The contrast amuses me.
In the course of my life, there have been a handful of times I discovered an idea that changed the way I thought about the world. The first occurred when I picked up Nick Bostr
Alright thank you that's enough.
The first occurred when I picked up Nick Bostrom’s book “superintelligence” and realized that AI would utterly transform the world.
"The first occurred when I picked up AI propaganda and realized the propaganda was true"
Hmm, how significant are we talking
predicted IQ of about 900
lol
LOL -- looking at the comments: "can somebody open a manifold market so I can get a sense of the probabilities?"
And yet the market is said to be "erring" and to have "irrationality" when it disagrees with rationalist ideas. Funny how that works.
It seems pretty obvious to me, and probably to many other people in the rationalist community, that if AGI goes well, every business that does not control AI or play a role in its production will become virtually worthless. Companies that have no hope of this are obviously overvalued, and those that might are probably undervalued (at least as a group).
asking the important questions: if my god materializes upon the earth, how can I use that to make a profit?
the cell’s ribosomes will transcribe mRNA into a protein. It’s a little bit like an executable file for biology.
Also, because mRNA basically has root level access to your cells, your body doesn’t just shuttle it around and deliver it like the postal service. That would be a major security hazard.
I am not saying plieotropy doesn't exist. I'm saying it's not as big of a deal as most people in the field assume it is.
Genes determine a brain's architectural prior just as a small amount of python code determines an ANN's architectural prior, but the capabilities come only from scaling with compute and data (quantity and quality).
When you're entirely shameless about your Engineer's Disease
This is quite a grandiose plan for someone writing a LessWrong blog post. And there’s a decent chance it won’t work out for either technical reasons or because I can't find the resources and talent to help me solve all the technical challenges.
The phrase "technical reasons" is doing an absolutely majestic amount of work in this sentence.
If only he were neither constrained by technical hurdles or resources, dang.
starts reading
looks at the scrollbar size
nope
If not for that pesky FDA, rats would develop the most bizzare case of liver failure that medicine has ever seen and took over the world with their superior intellect, any day now, you'll see
Credit where it's due, I appreciate them leading with a TL;DR link to a summary. Unfortunately the summary was also too long and I didn't read it. I'm happy for you though. Or sorry it happened.
LLM's are great you doubters, look this guy even used it to get unshadowbanned on twitter.
Re the subject at hand 250+ upvotes oof. And once I again I feel the desire to write a 'gene editing to improve intelligence is immoral because of the higher depression risk that correlates with higher intelligence. But that would backfire very quickly (esp if we hook into other reasons why very smart people with no economic resources might even be extra depressed and poof we are back at eugenics and keeping the Morlocks poor away from intelligence improvements).
Vague association with eugenics make some academics shy away
This guys profile:
currently doing independent research on gene therapy with an emphasis on intelligence enhancement.
Gosh. (I honestly had not noticed these 2 quotes before I mentioned my trollpost + risk).
that's just brave new world with extra steps
I have thought that for the distopia a lot of the right fears brave new world fits a lot better than 1984. But that is unrelated to this.
I clicked the original LW link (not the archive link) and got a malware warning.
Well he really could use a boost lol
he's even better in the comments, absolutely unhinged
Maybe he'll get to the point where he thinks you could do it by changing mouth bacteria to CRISPR your shit. Cure gum disease at the same time!
@dgerard god almighty there's so much of it
I mean personally I would fix things that are broken first. The last thing I might want to edit is anything nerve related and even then problems before enhancements. Im pretty happy with my intellect level and could not see messing with that unless it clearly was needed in the sense that I fell below one standard deviation of average intellect.
From the comments:
Effects of genes are complex. Knowing a gene is involved in intelligence doesn't tell us what it does and what other effects it has. I wouldn't accept any edits to my genome without the consequences being very well understood (or in a last-ditch effort to save my life). ... Source: research career as a computational cognitive neuroscientist.
OP:
You don't need to understand the causal mechanism of genes. Evolution has no clue what effects a gene is going to have, yet it can still optimize reproductive fitness. The entire field of machine learning works on black box optimization.
Very casually putting evolution in the same category as modifying my own genes one at a time until I become Jimmy Neutron.
Such a weird, myopic way of looking at everything. OP didn't appear to consider the downsides brought up by the commenter at all, and just plowed straight on through to "evolution did without understanding so we can too."
absolutely classic crank shit
I talked to some pretty well-qualified math PhDs with expertise in analytic number theory, algebraic number theory, and geometric number theory. While many of them were skeptical, none of them could point to any part of my proposed proof of Fermat's Last Theorem that definitely won't work.
I'm a mathematician and this is exactly what I was imagining lmao
I bet all of them pointed out the multifarious ways it could not work, though, and this guy heard "it shouldn't work... but it might".
Frankly, good; he removed himself from the gene pool and we can probably learn something from his remains.
That or we all get Kronenburg'd.
let's be clear: this guy is not going to stop until he's cooked his own brain out of his skull
Classic appeal to ignorance argument in use here.