In this case anon just want to search and replace text in file using various text editors, but he describes it funny way:
acme: very slow process because it requires using mouse and keyboard alternately
emacs: faster because you don't have to use mouse but requires pressing a lot of weird and complicated key combinations and use many modifier keys like ctrl, alt and so on, in this case description is a bit exaggerated. Also see emacs pinky syndrome
vim: portrayed as simple and efficient, anon is probably vim user.
Acme doesn't stand for some generic editor! It's the famous acme text editor by Rob Pike. It's an interesting editor, very different from Emacs or Vim, and yes, very mousey. In this video Russ Cox gives a great overview: https://youtu.be/dP1xVpMPn8M
I map caps-lock to escape on short press, caps-lock to ctrl when pressed with another key, and both shifts to caps-lock when pressed together. It's more intuitive than it sounds, trust me.
In the ancient times, the escape button wasn't at the upper left corner, but to the left of Q (ADM-A3). Vi (and by extension Vim) just haven't adapted to a different keyboard layout.