You'll want to download the correct dependencies for the bottle after creating it. Off the top of my head.
vcredist 2022
dotnet 4.8
dotnetcore3
d3dx9
d3dx11
d3compiler
You'll want to download Wine-GE, which may or may not be included in bottles. Otherwise, I hear the latest Caffe works pretty well, but I have never personally tried it.
Also, enable DXVK and VKD3D setting the latest ones for that.
Lastly, ensure the renderer is set to Vulkan instead of the default GL.
This is all off the top of my head and I don't remember where these settings are exactly but usually all within the bottle. I don't use flatpak bottles, so I'm not sure what dependencies are already included. Someone feel free to correct me.