Background A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion of m...
Background
A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Yet, its underlying pathomechanisms remain poorly elucidated.
Results
Upon physical activity, affected patients exhibit a reduced systemic oxygen extraction and oxidative phosphorylation capacity. Accumulating evidence suggests that these are mediated by dysfunctions in mitochondrial capacities and microcirculation that are maintained by latent immune activation, conjointly impairing peripheral bioenergetics. Aggravating deficits in tissue perfusion and oxygen utilization during activities cause exertional intolerance that are frequently accompanied by tachycardia, dyspnea, early cessation of activity and elicit downstream metabolic effects. The accumulation of molecules such as lactate, reactive oxygen species or prostaglandins might trigger local and systemic immune activation. Subsequent intensification of bioenergetic inflexibilities, muscular ionic disturbances and modulation of central nervous system functions can lead to an exacerbation of existing pathologies and symptoms
What kind of stuff would you encourage posting?
Interesting studies, relevant resources? Or would you prefer discussion type posts?
Or all of the above?
Cool yeah!
I’m really passionate about my field. And a lot of medical professionals have prejudice or believe outdates stereotypes about it. So I’d love to make some posts about it if that’s okay?
Hey I have a MD with residency in Neurology. Then I did a PhD in Neuroimmunology with board certification.
I’m currently doing a hectic mix of teaching two med courses, working on Long COVID research (biomarkers), and working in an understaffed long COVID (now post-viral disease) clinic.
Nice to meet you.
I mostly lurk on lemmy, but that’s because I haven’t found a place I’d like to consistently contribute yet. Maybe here?
LolAh sorry, the genome of octopus’ mating is only 99.99 something % similar. Not 100%. Rounding reflex.
Are octopus related to octopus? I mean technically they’re 100% related, but also they aren’t related as related implies not being. Depends on your interpretation.
If you’re confused: Birds are dinosaurs, crocodiles aren’t; note the “closest living relatives”
I found college classes with small sizes were the worst as they would always adapt to the slowest learners who put no effort. While large lectures don’t do that.
Look up plague poems on bluesky, was posted yesteday author provided source in replies iirc
If you’re healthy.
Sucks to be disabled or immunocompromised or at risk in any other way…
Also, it’s still killing at much higher rates than the flu.
And I won’t even start getting into Long COVID, which I’m currently researching. But it is a major crisis. 2-4 million people unable to work in the US because of it.
FYI, you seem to be new here and seem not to be far-left. For your future enjoyment of lemmy, note that Lemmy.ML is a communist instance and therefore you may not like some of the content there.
When I was into gym and building muscle mass this confused the hell out of me at first.
Not really.
There have been extensive sociological studies over this. Condition in a capitalist society and the promotion of the “homo economicus” model continually reinforces “greediness” and leads to people in capitalist societies being far “greedier” on average.
It isn’t a natural thing, it is conditioned. Obviously everyone is greedy to an extent. But in anthropological examinations of different forms of societies, altruism scored far higher than greediness in non-capitalistic societies.
Kate Raworth, Oxford Economist, wrote an excellent chapter about this in her book called “doughnut economics”. The chapter is “Nurture Human Nature”.
The view that all humans are greedy and rational was promoted by Adam Smith and John Stuart Mill and is the precursing foundation of capitalism. But modern economics have rejected this view as it has been proven to be inaccurate, and increasingly rely on theoretical models built within behavioural economics.
Critical of capitalism ≠ Socialist
There’s a lot of nuance you’re missing out on in this simplistic statement.
I obviously oppose any authoritarian regime regardless of the economic system.
Does this statistic include calories fed to livestock or not?
Lac Léman, is the french word for what english people call lake geneva (all the region around lac léman is french speaking).
Léman comes from celtic “lemann” which means lake.
So lac léman is the lake lake. Given it is the biggest lake in western europe, not a bad name.
cross-posted from: https://mander.xyz/post/16143715
That’s not how these collegues treat them.
They act like you can basically “think yourself out of” most mental illnesses.
unpopular opinion is not the same thing as academic literature lol makes sense.
Though I found the points to be well thought it (if not clearly written in a rush).
Also to be fair given the post, they could likely be a med student or something. Most people aren’t aware of the specific biological factors they listed nor some of the conditions, as OP used some medical terminology not often seen used by layman.