CRISPR used to remove extra chromosomes in Down syndrome and restore cell function
Japanese researchers have successfully eliminated the extra chromosome responsible for Down syndrome using CRISPR gene editing.
This opens the door to so many possibilities. I'm just a dumb-dumb, but skimming through this: https://pmc.ncbi.nlm.nih.gov/articles/PMC7508700/ it seems that organ xenotransplantation might become a reality in the not too distant future.
5 Sex reversal SRY, Sp1 CRISPR-Cas9,
Fun times ahead 😀
Actually awesome times ahead, thanks for the link!
works while as the egg, but not as grown human.
This is not true on multiple levels. One of the benefits of the Crispr technique is it can be used in vivo, so this sort of treatment will potentially be able to be used at any point in an individual's life. But also, trisomy-21 isn't present in sperm or eggs, it's a mistake in cell division early in fetal development, so applying this technique to an egg would have no purpose or effect.
trisomy-21 isn't present in sperm or eggs, it's a mistake in cell division early in fetal development
This is incorrect. Non-disjunction (where chromosomes incorrectly separate) typically happens during the formation of egg or sperm. (We know this because most everyone with down syndrome has three different chromosome 21 instead of two identical copies of one chromosome.)
This is awesome news but I thought this news was already from a few months ago.
*In mice
God I’m kinda sick of the clickbait headlines
This research was conducted on four human induced pluripotent stem cell lines:
In our previous work, we generated a trisomy 21 iPS cell line derived from skin fibroblasts and three induced disomy iPS cell lines with different combinations of HSA21 (ΔP, ΔM1, and ΔM2) using the chromosome elimination technique
Here's the previous work
How did you even come to the conclusion mice were involved? Mice aren't mentioned anywhere
