3w ago

Antidepressant of the masses

Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain

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Does it elicit a psychoactive reaction or does it affect TRPV3 in vitro?
be honest David Beckham meme
- In vivo in mice
- is TRPV3 even involved in any way because last time i've checked some of best evidence points in direction of TrkB
I want to see someone correct that commentor by telling them frankincense was the name of the doctor not the monster.
- Frankincense was actually the name of the wise man.
  
  Knowledge is knowing Frankincense is the doctor. Wisdom is knowing Frankincense is the monster
- The monster's name was Adam Frankincense.
I got some frankincense and lit it, now my apartment smells like smoke
- Just as John Frankincense intended.
incensole acetate has ~1/10th the anti-anxiety potency of valium, which is pretty darn high if you think about it!
myrrh is also psychoactive, but it’s a straight up opoid agonist. it was commonly used as a pain reliever before the widespread use of opium poppies. in high-ish concentrations folks report general euphorua, dream-like states, and even vivid/lucid dreams! i can personally attest to the first two hahah
- Next you're gonna tell me gold is psychoactive!
  
  Having lots of it would indeed make me happier :p
Now someone is going to make a Frankincense vapes
- Extract in a passive nasal inhaler device like Poy-Sian would probably work.
  
  Is that bottle actually labeled "Poy-sian" like poison?
So, uh, how would one make use of this knowledge?
- Probably shouldn't experiment with large doses of barely understood substances... But if someone really wanted to.
  You can buy Incensole Acetate from chemical companies, but it's like hundred dollars for a few milligrams. Would have been cool for it to be cheap this form because you could probably use it in a passive nasal inhaler device at that strength.
  However you can buy 4oz of frankincense resin for ~$30. I would imagine that will have much more of Incensole than a few mg. No idea if it would be easy to inhale in vapor form or if you would have to burn it.
  No idea how reputable these sites selling it are, but here is one.
  
  How have we allowed a substance used by a major religion for two millennia remain a "barely understood substance?"
Religion itself is said to be natural antidepressant. I do wonder if exposure by our ancestors to psychoactive substances is tied to the development of religion.
- Hell just the chords they play on the organ. You could probably write a song about licking envelopes in the style of a church hymn and get people to worship the Postmaster General.
  
  I mean, I have been looking for a cult to join, if you were looking to start one.
Uh yeah, how is that new? That was always the point of using the stuff.
- I figured it was traditionally used because it's what was given to baby JC by the three wise men, so it's considered holy in a sense
  
  It's a drug and has always been used as such. Why do you think that stuff was so valuable?
Here and I thought the smoke was meant to keep mosquitos away
- Maybe it doesn't actually keep them away but just gets them too high to be interested in biting.
  
  But the higher I get, the more interested in biting I become
I actually got my hands on Frankincense drops and started to eat them like crazy, when I decided to try one of them. It tasted like actual raw glass like rocks although I liked eating them and didn't knew why until now. Although they have almost zero to non taste, eating them was quite addictive in my experience
That’s what they used to call “Church Air”
So the Church has wine and antidepressants in its rituals...
Somewhere, Dr. Ammon Hillman has read this and is grinning maniacally.
- I was going to go with Marx. Turns out religion is the LITERAL opiate of the masses!
  
  Makes sense with Marx too I guess but Hillman, who has a doctorate in classics and a masters (I think) in one of the biosciences has been pushing for more awareness of the countless references to recreational and sacramental drug use in antiquity for over a decade now. He's not for everybody but he's read ancient Greek for over 3 decades and finds some pretty surprising accounts of it in neglected medical and other texts he continues to translate.
I'll stick with my family trait that means when we fight we get happy brain juice, I just wish boxing or MMA could trigger it but it doesn't. If the fight can't theoretically end with me getting gutted with a rusty knife I want nothing to do with it, I want to Cain someone's Able.
- Okay? Stay safe, I guess
  
  Eh I generally have to avoid activating that particular trait, it's rather unproductive. Also I shit talk a lot while in a fight and that could get me in deeper water due to fighting words laws.

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