Your guess is "the last digit is 2". This necessarily implies that your full guess is: "there exists a last digit, and that last digit is 2". I'll happily prove that wrong :)
Don't do it, buddy! They may look like the last digits of Pi because of all those zeroes that follow, but it's just a really long string of zeroes that starts up with random digits again after a while!
What's wrong with me, why am I getting so annoyed that the other comments are acting like there's actually a chance it's right? Are they just being funny, or do they actually think the question "what's the last digit of pi" makes sense? Even if they're wrong, why should I care?!
Nah, pi arises purely from math, it doesn't depend on the universe. The number we call pi would still be an irrational number even if the universe is a simulation that uses a rational approximation of pi.