I'll be honest that I first thought it said "longest running cartoon in each state" and spent way too long wondering why no states had any in common...
Kinda cool that almost every state has a cartoon associated with it, some more obvious than others
The city is, but the state is Washington. There's an episode they were out of state and it ends with them returning home with a Welcome to Washington sign visible.
Is The Simpsons set in Oregon canon? I know Matt Groening has said that he's from there and a lot of the characters are inspired by his real life family.
I haven't seen The Simpsons in ages since it stopped being good so I don't know if this is a new thing or the OP took some liberties.
Simpsons is specifically not from a specific state. Too many contradictory "clues" to the location. Honestly, I've always thought Massachusetts was the most likely - given the nearby ocean and the parody of the Kennedy family, but I do recall an old Reddit thread that had it worked out to be West Virginia!
Not sure I would really count Fetch! With Ruff Ruffman! As a cartoon. It's a PBS edu-game show hosted by a cartoon dog, the majority of the show is following the contestants doing science challenges, there's maybe 5 minutes of cartoon storyline per episode.
Life was missing its mystique.
My squeaky toys had lost their squeak.
And then, out of the blue, I saw the phone and BAM! My destiny is calling me!
Pitched my vision for a show.
They loved it! Thought I was a pro.
They got my contract back to find to their alarm a dog had signed.