Glad someone answered my question before I even got here! Figured it couldn't be too far off.
While this means the E. coli cells are technically displaying the game rather than actually running it, it’s still impressive to see Doom being ported in this way.
Ren also notes that the game is only able to run at one frame every 8.33 hours.
I can't run Doom, but I can run Level 9, "Fuel Station Launch", from Dark Forces 2, down to which extra enemies spawn and what items are removed when playing on each difficulty level.
It was on an old demo disc and I must have played that level a hundred times as a kid.
I'd have to play it or at least watch enough playthrough videos to be able to do this. The bastardized doom currently able to run in my head would probably offend people that have actually played the real game.