If you need secure boot on current (like intel gen 10+), Fedora Workstation. If you don't need secure boot, Linux Mint.
Fedora has the easiest way to make secure boot just work, it will even dual boot fine on the same disk although you should still backup the m$ partition if you actually need it. Fedora can do secure boot even with Nvidia.
Ubuntu can do some of the secure boot stuff like Fedora does, and there is the advantage of the stable kernel if you have Nvidia.
Note that "stable" as a label has nothing to do with its intuitive meaning like alpha/beta/testing/crashing etc. It is a term for servers and people that want to run very specific setups that will not require human intervention on embedded devices and servers. If you want to game or use the latest sw "stable" might be a pain. However, if what you are running is not kept up to date with the latest packages and libraries, a stable release may be the only way to run your stuff.
Overall these are the biggest factors on current hardware; secure boot yes/no, and up-to-date software needs yes/no.
I think your best bet for this is one of the spinoffs of enterprise Linux: fedora or openSUSE. both are very solid ootb, and have starting configurations that are generally good.
The microos or silverblue variants respectively are really promising as well, but still have some caveats.
What are you trying to build? A work laptop that you're going to take on trips, a gaming computer, a server? Something else?
For you, what is too much hassle? Are you a new Linux user or an experienced user with no spare time? What are you accustomed to doing when you install an operating system and what do you expect to be preinstalled?
I have 2 screens, I like to have the same panel on each screen, so when I use one in fullscreen, I can use the other one. So far, the only Desktop Environment that can give me that without too much difficulties, is KDE (even if I had to do it manually).
If you have the same use, maybe Kubuntu is a great choice. Tuxedo OS would be the same as Kubuntu, but you don't have to change the priority of the package manager, because the snaps are already disabled. ( they got another load of malicious softwares in the snapstore recently, and some snap might not be as good as .deb or flatpak).
If not, Linux Mint is an out of the box distribution. If your hardware is the most recent one, they have a "edge iso".
openSUSE Tumbleweed is pretty comfy. Btrfs snapshots enabled by default so it's really hard to break it. I've been using it for about 8 months now and haven't had any big issues.
Don't know which one to recommend but I would never recommend Ubuntu. It is full of bugs to me. I used it for years without issues but now it is impossible for me. Installed it on my girlfriend's laptop recently and she has the same bugs I had years ago when I dropped it : network disconnects randomly and she has to reboot, bluetooth won't reconnect sometimes... I can help but it is definitely not working out of the box for users who are not into tech.
I would highly recommend fedora kinoite, it's immutable so the system doesn't break without you trying very hard, well configured out of the box, and uses flatpak for apps so the system can be stable and the apps can be updated regularly!
A lot of folks would recommend Ubuntu as a start but it’s very bloated af so starting on Linux Mint or Zorin/Elementary OS (if you want a windows/macos experience in your distro) would be a great start imo
If you have to ask it probably means the answer is one of the following:
Mint
Ubuntu
Pop!_os
In that order. Mint will be most likely the answer if your hardware is pretty normal. Ubuntu will be the answer if you're willing to give up some security and privacy for east of use (pro-tip: if this is your mentality I'd recommend a different OS and dual booting while you learn). Pop!_os will be the answer if you don't need super up to date software and want all your hardware to work because you have something odd
Personally I would strongly advise towards Mint. I used to direct people away from it but I've learned this was a bias I had against them for mishandling a security thing a long time ago that they've since become leaders in the security space for general use Linux operating systems.
Ubuntu LTS. Far more polished than Mint, regardless of the Snap hatred you will hear. And Snap is a bit annoying, but not one bit the evil some people will convince you it is. Will not break unless something extremely stupid is done. And since it is based on Debian Unstable, it receives latest packages plus is first preference Linux platform for corporate and general software.
Bazzite. It's made for gaming, but it just works, 0% hassle. I used to love doing lots of stuff with the terminal in arch, but since I switched I haven't opened the teminal once.
I would recommend Vanilla OS, especially Vanilla OS 2 once it's released. It's a very stable distro with an immutable system. It also allows you to install arch, debian, fedora, etc. packages using the apx package manager